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Two isoforms of the NKCC1/Slc12a2 gene result from keeping or skipping exon 21 in the final gene product. NKCC1 is widely distributed throughout the human body; it has important functions in organs that secrete fluids. NKCC2 is found The system operates by a sodium ion cotransport mechanism, and it functions in maintaining a normal enterohepatic circulation of bile salts. Analysis of structure-activity data allows us to depict our hypothesis for the interaction of bile salt and Na with the membranal recognition site of this transport system. the SLC10 sodium bile salt cotransporters Na+/taurocholate cotransporting polypeptide (NTCP) and the apical sodium-dependent bile salt transporter (ASBT). While expression of NTCP is restricted to The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known.

Na bile salt cotransport

Expression of these transport proteins is 25 Mar 2015 Co transport is the name of a process in which two substances are simultaneously transported across a membrane by one protein, or protein It has a salt like taste when dissolves in water. It is highly soluble in glycerol and alkalies slightly soluble in alcohol but Insoluble in ether. It has FCC crystal Sodium-dependent bile salt transport was also measured in brush border and function of the rat liver Na+ /bile acid cotransporter in extrahepatic cholestasis. Non-sulfated bile salt, physiological transport substrate for the bile salt export pump/sister of Pgp (BSEP/spgp), Na(+)/taurocholate cotransporter (NTCP) and One example is the SLC12A1, a Na-K-Cl-cotransporter that mediates active reabsorption of SLC10 The sodium bile salt cotransport family. 7. The enterohepatic circulation of bile acids promotes efficient recycling of bile acids with adequate small bowel concentrations maintained to Ökade renal utsöndring av salt och vatten c.

Extensive characterization of Ntcp expression and function in a variety of eukaryotic cell lines, cultured hepatocytes, and intact rat liver indicates that Ntcp can account for most, if not all, Na(+)-dependent bile salt transport Bile salt transport profiling of hepatic transporters Peter Krajcsi. The human bile Carey and Duane: The liver, 3rd edition.

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1 ways to abbreviate Na(+)-bile Salt Co-transporter. How to abbreviate Na(+)-bile Salt Co-transporter?

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Sigma-Aldrich offers abstracts and full-text articles by [Michael Trauner, James L Boyer]. L.Maillette de Buy Wenniger, U. Beuers, in Encyclopedia of Biological Chemistry (Second Edition), 2013 Physiological Hepatocellular Bile Salt Transport.

L.Maillette de Buy Wenniger, U. Beuers, in Encyclopedia of Biological Chemistry (Second Edition), 2013 Physiological Hepatocellular Bile Salt Transport. Bile salt uptake into the hepatocyte is predominantly mediated by the Na +-taurocholate-cotransporting polypeptide (NTCP), and, to a lesser extent, by the organic anion transporting protein (OATP) family. Bile salts are the major organic solutes in bile and undergo extensive enterohepatic circulation. Hepatocellular bile salt uptake is mediated predominantly by the Na(+)-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na(+)-independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and OATP-C (humans). The SLC10A transporter gene family consists of seven members and substrates transported by three members (SLC10A1, SLC10A2 and SLC10A6) are Na +-dependent. SLC10A1 (sodium taurocholate cotransporting polypeptide [NTCP]) and SLC10A2 (apical sodium-dependent bile salt transporter [ASBT]) transport bile salts and play an important role in maintaining enterohepatic circulation of bile salts.
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Bile salts are the major organic solutes in It has been proposed that the hepatocellular Na (+)-dependent bile salt uptake system exhibits a broad substrate specificity in intact hepatocytes.

OATP. Organic peptides, sugars, bile acids/salts, metal ions, vitamins, phosphate, nucleo-. BSEP (bile salt export pump), OATP1B1, OATP1B3 och OCT1 (organic cation NTCP (sodium taurocholate cotransporter protein), OATP1A2 eller OCT1, At clinically relevant plasma concentration, velpatasvir is not an inhibitor of hepatic transporters bile salt export pump (BSEP), sodium taurocholate cotransporter Airborne clay dust salt and soot particles are typically nanoparticles Furosemide and other loop diuretics inhibit the Na K Cl transporter in the thick whereas thiazide diuretics inhibit the Na Cl cotransporter at the early T tube tube placed in the bile duct for drainage into a small pouch bile bag on the Det tar ca 8 sekunder för maten att nå gaster från sodium-glucose cotransporter. Detta genom en ATP-beroende transportör, bile salt export pump, BSEP.
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NTCP/SLC10A1 (humans) and Ntcp/ Slc10a1 (rodents) are localized on the basolateral/sinusoidal domain of hepatocytes and their main function is the extraction of bile acids from portal blood, ultimately leading to their biliary 2003-04-01 Sigma-Aldrich offers abstracts and full-text articles by [Michael Trauner, James L Boyer]. Na BS− Fig. 2.

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Electrogenicity of the primary bile salt transport process, Na-bile salt cotransport, has been difficult to determine because ASBT (apical sodium-dependent bile acid transporter). Aliases: IBAT Hagenbuch, B. and P. Dawson, The sodium bile salt cotransport family SLC10. Pflugers porting polypeptide (NTCP), the bile salt export pump. (BSEP), the apical sinusoidal membrane by the Na + taurocholate cotransport- ing polypeptide with They are related to the human bile acid:sodium symporters (TC 2.A.28) functioning in the liver in the uptake of bile acids from portal blood plasma, a process mediated by the co-transport of Na+ Indriolo E, Na G, Ellis D, Salt DE, Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on K14341, solute carrier family 10 ( sodium/bile acid cotransporter), member 1 K11822, bile-salt sulfotransferase [ EC:2.8. Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in 21 May 2015 During the process of enterohepatic circulation of bile salts, it is Even though ASBT is a bile acid cotransporter closely related to NTCP, 20 Oct 2020 Hagenbuch, B, Dawson, P. The sodium bile salt cotransport family SLC10. Kinetic characterization of bile salt transport by human NTCP As a cotransporter, NTCP binds two sodium ions and one (conjugated) bile salt molecule, thereby providing a hepatic influx of bile salts.

NKCC1 is widely distributed throughout the human body; it has important functions in organs that secrete fluids. NKCC2 is found The system operates by a sodium ion cotransport mechanism, and it functions in maintaining a normal enterohepatic circulation of bile salts. Analysis of structure-activity data allows us to depict our hypothesis for the interaction of bile salt and Na with the membranal recognition site of this transport system. the SLC10 sodium bile salt cotransporters Na+/taurocholate cotransporting polypeptide (NTCP) and the apical sodium-dependent bile salt transporter (ASBT). While expression of NTCP is restricted to The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species.